Gum Disease and Alzheimer’s: Scientists Study the Oral–Brain Connection

Researchers have discovered that Porphyromonas gingivalis, a bacterium strongly linked to periodontal (gum) disease, has been found in the brains of some people who died with Alzheimer’s disease.
Key findings from studies:
• P. gingivalis DNA detected in Alzheimer’s brain tissue
• The bacterium produces gingipains, toxic enzymes that damage cells
• Gingipains can affect brain proteins linked to Alzheimer’s, including:
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Amyloid beta plaques















